A reaction follows the mechanism below. The first three steps are rapid and reversible; the final step is slow.
Step 1 E ⇌ F K₁
Step 2 F + G ⇌ H K₂
Step 3 H + G ⇌ I K₃
Step 4 I → products kₛ
Define the overall equilibrium constant for formation of I from E and two G molecules as K_overall = K₁K₂K₃. Which rate law is most consistent with this mechanism?
a) rate = ksKoverall[E][G]
b) rate = ks[E][G]2
c) rate = ksKoverall[E][G]2
d) rate = ksKoverall2[E][G]2