Chemistry · Nucleic Acids & the Molecular Basis of Information
Problem
For a double strand DNA, one strand is given below: The amount of energy required to split the double strand DNA into two single strands is _____ kcal mol⁻¹. [Given: Average energy per H-bond for A-T base pair = 1.0 kcal mol⁻¹, G-C base pair = 1.5 kcal mol⁻¹, and A-U base pair = 1.25 kcal mol⁻¹. Ignore electrostatic repulsion between the phosphate groups.]