An enzyme accelerates a biochemical reaction by holding two substrate molecules in a fixed orientation within a non-covalent active site pocket. No covalent bonds are formed between the enzyme and the substrates during the rate-determining step. Which type of catalysis is MOST directly illustrated by this description?
a) Covalent (nucleophilic) catalysis
b) Binding (orientation) catalysis
c) Surface (heterogeneous) catalysis
d) General acid–base catalysis